In order to facilitate the effective transformation of academic-research into outcome and to increase the capability to innovate and to apply state-of-art technologies, Macao Polytechnic Institute, GuangDong University of Foreign Studies and Global Tone Communication Technology agreed to establish the Chinese-Portuguese-English Machine Translation Laboratory, mainly to collaborate widely in the fields of Basic Technology Research, Applications of Innovative Technologies and Professional Talent Development. The main research areas of this laboratory include Basic Technology Research, Chinese-Portuguese-English Corpora Processing, the Engine of Machine Translation, Corpora Refinement and Classification, Natural Language Processing Technologies, Machine Translation Based on Sentence Templates, Language Big Data Analysis, and different types of Applied Research. The research outcomes of different types of co-operating projects from this laboratory will be utilized by different teaching and research events, and will be beneficial to cultivate high quality professional talents. With their own unique strengths and through the establishment and operation of this Chinese-Portuguese-English Machine Translation Laboratory, Macao Polytechnic Institute, GuangDong University of Foreign Studies and Global Tone Communication Technology aim to assist Macao S.A.R. to be the Trade Service Platform between China and Portuguese-speaking Countries, as well as to provide different innovative applied services.